What does a high SDMA mean in cats?

What does a high SDMA mean in cats?

​ Any increase in SDMA concentration above the reference interval (greater than 14 µg/dL in cats and adult dogs; greater than 16µg/dL in puppies) is considered meaningful. An elevated SDMA concentration is a reflection of impaired glomerular filtration rate (GFR). Both primary kidney disease.

Can feline kidney failure be reversed?

If diagnosed in time, acute renal failure can often be reversed. It can happen in cats of any age and typically results from poisons, trauma, infection, organ failure, urethral blockages, dehydration and other causes.

What is the life expectancy of a cat with kidney disease?

The median life expectancy for cats diagnosed in stage III kidney disease at baseline was 1.86 years (679 days), with some surviving up to 5.75 years. Cats determined to be in stage IV kidney disease at baseline had the worst prog- nosis, with a median survival of only 1.16 months (35 days).

Can UTI cause elevated SDMA?

SDMA is a more sensitive indicator of kidney function than creatinine in AKI as well as CKD and increases earlier. In pets like Reese, an increased SDMA in the face of a urinary tract infection should lead to additional investigation and a consideration for more aggressive treatment for pyelonephritis.

Can dehydration cause high SDMA in cats?

If dehydration results in a prerenal azotemia reflecting a reduction in GFR, then SDMA should also increase.

Is Tuna good for cats with kidney disease?

Tuna is high in phosphorus and while a healthy cat may cope with this, it won’t be good for cats with kidney disease. Raw fish can contain thiaminase which is an enzyme that destroys thiamine, or vitamin B1. Too much raw fish in a cat’s diet can, therefore, lead to thiamine deficiency.

What are the 4 stages of kidney disease in cats?


TABLE 2. IRIS Guidelines: Staging Feline CKD by Serum Creatinine Concentration
Stage 2 Mild Renal Azotemia 1.6 to 2.8 140 to 250
Stage 3 Moderate Renal Azotemia 2.9 to 5 251 to 440
Stage 4 Severe Renal Azotemia > 5 > 440

How reliable is SDMA?

IDEXX SDMA is a reliable marker for kidney disease, that is both sensitive and specific, increasing on average when there is a 40% reduction in GFR due to cancer or other conditions. Cancer patients with increased SDMA should be carefully managed since structural kidney disease is often present that results in CKD.

Can SDMA be falsely elevated?

SDMA correlates with strongly with GFR. There are no known interferences that are expected to cause a falsely increased SDMA. SDMA increases only when GFR is reduced. However, if GFR is reduced with prerenal or postrenal azotemia, then SDMA will increase accordingly.

Do cats feel pain with kidney failure?

If your cat is suffering from acute kidney failure you may also notice an arched back or stiff-legged gait, symptoms that your cat’s kidneys are causing pain. Chronic kidney failure gradually progresses over years, and the signs may not be noticeable.

What are the symptoms of end stage kidney disease in cats?

Symptoms of end stage kidney failure in cats include dull sunken eyes, inability to walk, body odour, incontinence in bladder or bowels, refusal to eat or drink, seizures, confusion, pacing and restlessness, withdrawing, hiding and running away.

What is stage 4 kidney failure in cats?

Stage 4: The creatinine level is higher than 5.0, which means that 90% of kidney functions have been lost. At this stage, your cat may be suffering quite a bit, so it is important to keep your feline friend as comfortable as possible.