Which antibiotics can cause thrombocytopenia?

Which antibiotics can cause thrombocytopenia?

Medicines Known to Cause DITP

Can amoxicillin cause thrombocytopenia?

A score of 5 was obtained, and drug-induced thrombocytopenia was shown to be a probable adverse event of amoxicillin/clavulanic acid. Because the thrombocytopenia occurred due to a penicillin derivative, similar cases with penicillin- and cephalosporin-induced thrombocytopenia were reviewed.

Why do antibiotics cause thrombocytopenia?

Vancomycin-induced thrombocytopenia is thought to occur through a hapten-drug mechanism because vancomycin binds to platelet glycoproteins, leading to the generation of antibodies that bind to the platelet surface and cause cell lysis.

What drugs are contraindicated with thrombocytopenia?

Which medications are contraindicated in the treatment of immune thrombocytopenia (ITP) during pregnancy?

• Cyclosporine.
• Dapsone.
• Thrombopoietin receptor agonists.
• Alemtuzumab.
• Rituximab.

What medications cause platelets to drop?

Certain medications can reduce the number of platelets in your blood. Sometimes a drug confuses the immune system and causes it to destroy platelets. Examples include heparin, quinine, sulfa-containing antibiotics and anticonvulsants.

How is drug induced thrombocytopenia treated?

Treatment of DITP involves discontinuation of the offending drug. The platelet count usually starts to recover after 4 or 5 half-lives of the responsible drug or drug metabolite. High doses of intravenous immunoglobulin can be given to patients with severe thrombocytopenia and bleeding.

What is the most common cause of thrombocytopenia?

Autoimmune disease which causes ITP. ITP is sometimes associated with other autoimmune conditions such as lupus. Bone marrow diseases, including aplastic anemia, leukemia, certain lymphomas and myelodysplastic syndromes. Cancer treatments like chemotherapy and radiation therapy.

What medications can affect platelet function?

Drugs. Aspirin, other NSAIDs, inhibitors of the platelet P2Y12 adenosine diphosphate (ADP) receptor (eg, clopidogrel, prasugrel, ticagrelor), and glycoprotein IIb/IIIa receptor inhibitors (eg, abciximab, eptifibatide, tirofiban) may induce platelet dysfunction.

Is drug induced thrombocytopenia reversible?

Treatment of DITP involves discontinuation of the offending drug. The platelet count usually starts to recover after 4 or 5 half-lives of the responsible drug or drug metabolite.

Which factor may cause a decreased platelet count?

Factors that can decrease platelet production include: Leukemia and other cancers. Some types of anemia. Viral infections, such as hepatitis C or HIV.

What drugs cause platelet dysfunction?

What are the four mechanisms of thrombocytopenia?

There are four primary causes of thrombocytopenia: hypoproliferation (lack of production), sequestration, consumption (utilization), and destruction. Sampling or laboratory artifact may also lead to falsely low platelet counts.

Does amoxicillin cause thrombocytopenia?

A score of 5 was obtained, and drug-induced thrombocytopenia was shown to be a probable adverse event of amoxicillin/clavulanic acid. Because the thrombocytopenia occurred due to a penicillin derivative, similar cases with penicillin- and cephalosporin-induced thrombocytopenia were reviewed.

Which antimicrobials may cause thrombocytopenia?

A wide range of commonly used antimicrobials have been suspected to cause thrombocytopenia, including beta-lactams and fluorquinolones [ 9 ] (10).

What are the possible complications of ampicillin toxicity?

For Healthcare Professionals. Hypersensitivity. The eruption that is sometimes observed in ampicillin-treated patients with undiagnosed infectious mononucleosis is characterized by a delayed pruritic maculopapular erythematous rash that generally occurs 5 to 10 days after ampicillin therapy is initiated.

What causes seizures in ampicillin toxicity?

Seizures have been reported in patients with high serum concentrations of ampicillin, although these patients were otherwise very ill. High cerebral spinal fluid (CSF) levels of some penicillins are known to be potentially neurotoxic, and the CSF concentrations of ampicillin rise significantly in meningitis.