General

What is the presentation of malaria?

What is the presentation of malaria?

Symptoms of malarial infection are nonspecific and may manifest as a flulike illness with fever, headache, malaise, fatigue, and muscle aches. Some patients with malaria present with diarrhea and other gastrointestinal (GI) symptoms. Immune individuals may be completely asymptomatic or may present with mild anemia.

What is the classic clinical presentation of malaria?

The most characteristic symptom of malaria is fever. Other common symptoms include chills, headache, myalgias, nausea, and vomiting. Diarrhea, abdominal pain, and cough are occasionally seen.

How do you confirm cerebral malaria?

Diagnosis. Diagnosis of cerebral malaria requires demonstration of asexual form of P. falciparum in peripheral blood smear, in thick and thin blood smear films stained by Giemsa stain.

What is the management of cerebral malaria?

Patients should be on oral regime as soon as they are able to tolerate it to complete 5-7 days of quinine therapy. Doxycycline should also be administered in the dose of 3mg/kg once a day for 7 days to achieve better cure rates.

How does malaria cause cerebral malaria?

Malaria deaths are usually related to one or more serious complications, including: Cerebral malaria. If parasite-filled blood cells block small blood vessels to your brain (cerebral malaria), swelling of your brain or brain damage may occur. Cerebral malaria may cause seizures and coma.

What causes cerebral malaria?

Cerebral malaria is the most severe pathology caused by the malaria parasite, Plasmodium falciparum.

What is the pathophysiology of cerebral malaria?

Pathogenesis of cerebral malaria is due to damaged vascular endothelium by parasite sequestration, inflammatory cytokine production and vascular leakage, which result in brain hypoxia, as indicated by increased lactate and alanine concentrations.

Which of the following is drug of choice in cerebral malaria?

Quinine is currently, drug of choice. Artimisinin derivatives are equally effective and can be used by intramuscular route. In severe cases exchange blood transfusion may be an effective alternative.

What is the difference between meningitis and cerebral malaria?

Meningitis causes inflammation of the meninges which is the protective membranes surrounding the in the brain and spinal cord. The inflammation is caused by an infection in the fluid surrounding the brain or spinal. Malaria is a disease caused by a parasite that travels in mosquitos and can be very serious.

What are the complications of cerebral malaria?

Other common complications of cerebral malaria, such as convulsions, hypoglycemia and hyperpyrexia, should be prevented or detected and treated early. Fluid, electrolyte and acid–base balance may need correction. Skilled nursing care of the unconscious patient is crucial.

What is cerebral malaria PDF?

Cerebral malaria is the most severe pathology caused by the malaria parasite, Plasmodium falciparum. The pathogenic mechanisms leading to cerebral malaria are still poorly defined as studies have been hampered by limited accessibility to human tissues.

What is the other name of cerebral malaria?

Human cerebral malaria (HCM) is the most severe complication of P. falciparum infection and has attracted the attention of both clinicians and scientists since the discovery of the malaria parasite. HCM can occur in less than two weeks after a mosquito bite and may develop after 2 to 7 d of fever.

What is cause of cerebral malaria?

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