What is the difference between statins and ezetimibe?

What is the difference between statins and ezetimibe?

Ezetimibe inhibits cholesterol absorption in the intestine whereas statins inhibit cholesterol production primarily in the liver; so they have complementary effects.

What is the medicine ezetimibe used for?

It’s used to treat high blood cholesterol. This is when you have too much of a fatty substance called cholesterol in your blood. You may also be prescribed ezetimibe if you cannot take cholesterol-lowering medicines called statins, or if statins do not work for you. Ezetimibe is available on prescription only.

What is fenofibrate used for?

Fenofibrate is used together with a proper diet to reduce and treat high cholesterol and triglyceride (fat-like substances) levels in the blood. This may help prevent the development of pancreatitis (inflammation or swelling of the pancreas) caused by high levels of triglycerides in the blood.

What are the most common side effects of ezetimibe?

Some of the more common side effects that can occur with use of ezetimibe include:

  • diarrhea.
  • stuffy nose.
  • viral infection of your nose, throat, and airways.
  • joint pain.

Does ezetimibe affect blood pressure?

No, clinical studies haven’t shown Zetia to affect blood pressure.

Does ezetimibe cause high blood pressure?

Which is better atorvastatin or fenofibrate?

Results: Atorvastatin was more efficient in the reduction of total cholesterol, whereas fenofibrate was more efficient in the reduction of triglycerides. Only atorvastatin led to a significant reduction of LDL cholesterol and apolipoprotein B. Only fenofibrate increased high-density lipoprotein cholesterol.

Can fenofibrate damage your liver?

Serious liver damage warning: Fenofibrate can cause serious liver damage. This can occur within the first few weeks of treatment or after several months of treatment. It can require a liver transplant and may be life threatening.

Should ezetimibe be taken at night?

There is no specific time of the day that is best to take ezetimibe, as it works exactly the same whether you take in the morning, afternoon or at night. Ezetimibe is taken once a day, at the same time each day and it can be taken with or without food.

Is fenofibrate safer than statins?

At the end of the study, the group that took gemfibrozil had a 34 percent decrease in the risk of coronary heart disease, but there was no difference in the death rate. Overall, statins appear to have greater benefit than fibrates in decreasing the risk of both heart attacks and strokes.

Who should not take fenofibrate?

It should not be used in people younger than 18 years. The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs, including fenofibrate, more slowly.

Are fibrates safer than statins?

Are fibrates safer than statins? Both fibrates and statins are safe medications. Statins are established to reduce the risk for cardiovascular disease, but this has not been consistently proven for fibrate medications. Fibrates may be mainly given to reduce the risk of pancreatitis.

What can replace fenofibrate?

Fenofibrate Alternatives Compared

  • Vascepa.
  • TriCor.
  • Omega-3 polyunsaturated fatty acids.
  • Trilipix.
  • Lipofen.
  • Rosuvastatin.

Who should not take fibrates?

Fibrates generally should be avoided in combination with statins since they can inhibit statin metabolism, causing an increased risk of myopathy. Recommendations are to always to measure serum creatinine levels and renal function before using the two drugs simultaneously.

Which is better Lipitor or fenofibrate?

What are natural fibrates?

Oat bran is the best-known example; 1–2 ounces a day should reduce your cholesterol by 10%–15%. Other excellent sources include beans, barley, prunes, citrus fruits, apples, Brussels sprouts, broccoli, and apricots. Psyllium, a natural grain from India, is also rich in soluble fiber.

Is ezetimibe a cholesterol absorption inhibitor?

Ezetimibe was found to have an ED 50 value of 0.5 µg/kg/day for inhibiting the rise in plasma cholesterol levels in monkeys. The ED 50 values in dogs, rats, and mice were 7, 30, and 700 µg/kg/day, respectively. These results are consistent with Ezetimibe being a potent cholesterol absorption inhibitor.

What is an example of an inhibitory 5α reductase inhibitor?

Many plants, as well as their associated phytochemical constituents, have inhibitory effects on 5α-reductase. In addition, many of these compounds are also phytoestrogens. Examples include the following: Alizarin,. Azelaic acid, (sometimes combined with minoxidil hair solution). β-Sitosterol, one of many phytosterols.

How do 5-alpha reductase inhibitors work?

The enzyme 5-alpha reductase is present in your liver, skin, and prostate. This enzyme converts some of the testosterone you produce into dihydrotestosterone (DHT). DHT plays a role in prostate growth, acne, growth of facial hair, and male pattern baldness. The 5ARIs work by suppressing the 5-alpha reductase enzyme.

Does vitamin B2 have a 5A reductase inhibitor?

Riboflavin (vitamin B2). The berries of saw palmetto, a small palm native to the south east United States, possess a dual but weak 5a-reductase inhibition activity, due to their high content of phytosterols: β-sitosterol, stigmasterol, lupeol, lupenone, and cycloartenol. The lipido-sterol extract markedly inhibits both the human isoenzymes.