What is the density of benzimidazole?
Density: The mean density of Benzimidazole (CAS No. 51-17-2) was found to be 0.947 g/cm³ at 20°C and 974 hPa.
What is the nature of benzimidazole?
Benzimidazole is a heterocyclic aromatic organic compound. This bicyclic compound may be viewed as fused rings of the aromatic compounds benzene and imidazole. It is a colorless solid.
What is the structure of benzimidazole?
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|Synonyms||BENZIMIDAZOLE 1H-Benzimidazole 51-17-2 1H-Benzo[d]imidazole Benzoimidazole More…|
What is the molecular weight of benzimidazole?
118.14 g/molBenzimidazole / Molar mass
What is substituted benzimidazole?
The novel antiulcer drugs omeprazole, lansoprazole, and pantoprazole are members of the class of substituted benzimidazoles.
What is the use of benzimidazole?
The benzimidazole and its derivatives play a very important role as a therapeutic agent e.g. antiulcer and anthelmintic drugs. Apart from this the benzimidazole derivatives exhibit pharmacological activities such as antimicrobial, antiviral, anticancer, anti-inflammatory, analgesic, etc.
Which derivative is benzimidazole?
Flubendazole is an anthelmintic that is used to treat worm infection in humans. It is available OTC in Europe. Fenbendazole is a benzimidazole that presents a wide spectrum anthelmintic effect.
Is benzimidazole soluble?
water: soluble (hot)(lit.)
Which solvent is used for recrystallization of benzimidazole?
Typical Procedure for the Preparation of Benzimidazoles If further purification was needed, by recrystallization it was dissolved in EtOH (10 mL) and then poured into ice water (30 mL).
How do you make benzimidazole?
Place 27 g (0.25 mol) of o-phenylenediamine in a round bottomed flask of 250 ml and add 17.5 g (16 ml, 0.34 mol) of 90% formic acid. Heat the mixture on a water bath at 100 °C for 2 h. Cool and add 10% sodium hydroxide solution slowly, with constant rotation of the flask, until the mixture is just alkaline to litmus.
Is benzimidazole the same as fenbendazole?
Fenbendazole is also a benzimidazole anthelmintic which is metabolised in mammals to a series of other benzimidazoles including oxfendazole; it has a similar spectrum of activity and may also be administered to pigs and goats.
What is the function of benzimidazole?
How do you do benzimidazole recrystallization?
Filter off the synthesized crude benzimidazole by using the pump, wash with ice cold water, drain well and wash again with 25 ml of cold water. Recrystallisation: Dissolve the synthesized product in 400 ml of boiling water, add 2 g of decolourising carbon and digest for 15 min.
Which solvent is used for in synthesis of benzimidazole?
one-pot synthesis of 2-substituted benzimidazole derivatives from o-phynelyenediamine and substituted aldehydes were developed under zinc triflate in ethanol solvent at reflux temperature  as shown in Scheme 17.
What are the uses of benzimidazole?
Abstract. Benzimidazole and its derivatives are regarded as an important heterocyclic motif that exhibits a wide range of pharmaceutical applications including anticancers, antihypertensives, antivirals, antifungals, anti-HIVs, anti-convulsants, and anti-diabetics.
What is the recrystallization solvent for benzimidazole?
How is benzimidazole synthesized?
The synthesized benzimidazoles compounds were prepared from the condensation reaction between o-Phenylenediamine and various carbonyl compounds, in the presence of ammonium chloride as a catalyst. Ammonium chloride is a commercial and environmentally benign catalyst.
Which is the category of benzimidazole?
This compound belongs to the class of organic compounds known as benzimidazoles. These are organic compounds containing a benzene ring fused to an imidazole ring (five member ring containing a nitrogen atom, 4 carbon atoms, and two double bonds).
What is the solubility of benzimidazole?
Benzimidazoles have only limited solubility in water; consequently, minor differences in solubility tend to have a major effect on absorption. Thiabenzole is rapidly absorbed after oral ingestion Most of the drug is excreted in the urine as 5-hydroxythiabendazole
What is the vapor pressure of benzimidazole in the air?
If released to air, an estimated vapor pressure of 7.6X10-5 mm Hg at 25 °C indicates benzimidazole will exist in both vapor and particulate phases in the ambient atmosphere.
How does benzimidazole affect the environment?
Benzimidazole’s production and use as an intermediate in the synthesis of fungal pesticides (1) may result in its release to the environment through various waste streams. (1) Meister RT; Farm Chemicals Handbook 1999.
What is the standard state of benzimidazole in KPA?
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).?) Benzimidazole is a heterocyclic aromatic organic compound. This bicyclic compound consists of the fusion of benzene and imidazole. It is a colorless solid.