Miscellaneous

What is scaffold in combinatorial chemistry?

What is scaffold in combinatorial chemistry?

The combinatorial libraries can be structurally related by a central core structure, termed scaffold (ie. all compounds of library have a common core structure), or by a common backbone.

What is combinatorial chemistry in drug design?

Combinatorial chemistry involves the generation of a large array of structurally diverse compounds, called a chemical library, through systematic, repetitive and covalent linkage of various “building blocks”.

What is the principle of combinatorial chemistry?

Combinatorial chemistry is based on the principle of making a large number of chemical compounds rapidly on a small scale in small reaction cells. This practice is widely adopted by the pharmaceutical sector for use during the drug designing and screening stages.

What is combinatorial chemistry used for?

Combinatorial chemistry can be used for the synthesis of small molecules and for peptides. Strategies that allow identification of useful components of the libraries are also part of combinatorial chemistry. The methods used in combinatorial chemistry are applied outside chemistry, too.

What is meant by linker or an anchor?

What is meant by a linker or an anchor? a) The bond which links a molecule to a solid support.

What is split and mix synthesis?

The split and pool (split-mix) synthesis is a method in combinatorial chemistry that can be used to prepare combinatorial compound libraries. It is a stepwise, highly efficient process realized in repeated cycles.

What is relation between lead discovery and combinatorial chemistry?

Combinatorial chemistry is designed to support the. lead discovery process. It is a technique by which a large number of structur- ally distinct molecules can be synthesized together at a time and submitted. for focused or varied pharmacological assay.

How does combinatorial chemistry differ from traditional methods?

Combinatorial chemistry differs from traditional synthesis. In that, it involves the simultaneous reaction of one set of compounds with a second set of compounds to produce a set of products known as combinatorial library.

What is meant by a Privilaged scaffold?

The precise definition of a privileged scaffold has been debated in the literature; the two most common definitions are (i) a single molecule that binds or interacts with multiple targets and (ii) multiple molecules with the same molecular scaffold that are biologically active (6).

What is solid phase combinatorial synthesis?

A common combinatorial technique uses organic synthesis on solid support. Linker groups are attached to resin beads in the solid phase and the reactants are passed over in solution to make the intermediates and a final detachment-from-resin reaction is run to get the desired product out of the column.

What is mixed combinatorial synthesis?

 Parallel Synthesis: A single product is obtained in each different reaction. vessel.  Mixed Combinatorial Synthesis: Mixture of products are produced in each. reaction vessel.

What is meant by a scaffold?

Definition of scaffold 1a : a temporary or movable platform for workers (such as bricklayers, painters, or miners) to stand or sit on when working at a height above the floor or ground. b : a platform on which a criminal is executed (as by hanging or beheading)

What is meant by linker or anchor?

What is combinatorics example?

Combinatorics and Probability In probability theory, there are many applications of combinatorics. For example, when we find the probability of occurrence of a particular event A, we can use the below formula: P(A) = Probability that A occurs = Number of outcomes where A happen/Total number of possible outcomes.

What is combinatorial chemistry?

Combinatorial chemistry had been invented by Furka Á (Eötvös Loránd University Budapest Hungary) who described the principle of it, the combinatorial synthesis and a deconvolution procedure in a document that was notarized in 1982.

How is a combinatorial library synthesized?

The synthesized molecules of a combinatorial library are ‘cleaved’ from the solid support and mixed into solution. In such solution, millions of different compounds may be found. When this synthetic method was developed, it first seemed impossible to identify the molecules, and to find molecules with useful properties.

What is combinatorial chemistry in the drug discovery process?

In the drug discovery process, the synthesis and biological evaluation of small molecules of interest have typically been a long and laborious process. Combinatorial chemistry has emerged in recent decades as an approach to quickly and efficiently synthesize large numbers of potential small molecule drug candidates.

Do combinatorial chemistry libraries have drug-like properties?

When comparing the properties of compounds in combinatorial chemistry libraries to those of approved drugs and natural products, Feher and Schmidt noted that combinatorial chemistry libraries suffer particularly from the lack of chirality, as well as structure rigidity, both of which are widely regarded as drug-like properties.