What is a Steno 2 study?

What is a Steno 2 study?

Description: The goal of the trial was to evaluate the effect on cardiovascular disease of an intensive intervention regimen of behavior modification and polypharmacologic therapy compared with a conventional therapy regimen among patients with type 2 diabetes and microalbuminuria.

What is the Accord trial?

ACCORD is the first large clinical trial to compare the cardiovascular effects of a statin (simvastatin) and placebo, or inactive pill, to combination therapy of a statin (simvastatin) and a fibrate (fenofibrate) in high-risk adults with type 2 diabetes. The ACCORD lipid trial involved 5,518 participants.

What was the Sprint study?

The NIH Systolic Blood Pressure Intervention Trial (SPRINT), an NHLBI-supported study, was designed to answer three important research questions about how treating to a lower systolic blood pressure target—less than 120 millimeters of mercury (mm Hg)—affects the cardiovascular system, kidneys, and brain.

What is Carolina trial?

CAROLINA (CARdiovascular Outcome study of LINAgliptin versus glimepiride in patients with type 2 diabetes) is a multi-national, randomized, double-blind, active-controlled clinical trial that involved 6,033 adults with type 2 diabetes from 43 countries at more than 600 sites observed for a median duration of more than …

Is gliclazide insulin?

Gliclazide belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin.

What is the Sprint study in hypertension?

The Systolic Blood Pressure Intervention Trial (SPRINT) was designed to determine whether a systolic blood-pressure target of less than 120 mm Hg (intensive treatment) would be associated with a lower rate of clinical events than a systolic blood-pressure target of less than 140 mm Hg (standard treatment).

What drugs were used in Sprint trial?

Various classes of standard high blood pressure medicines were included in the formulary for the SPRINT trial, including diuretics, angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers, calcium channel blockers, and beta blockers, among others.

What is Tecos trial?

TECOS: A Randomized, Placebo Controlled Clinical Trial to Evaluate Cardiovascular Outcomes After Treatment With Sitagliptin in Patients With Type 2 Diabetes Mellitus and Inadequate Glycemic Control.

What is Carmelina trial?

CARMELINA® is a multi-national, randomized, double-blind, placebo-controlled clinical trial that involved 6,979 adults with type 2 diabetes from 27 countries at more than 600 sites observed for a median duration of 2.2 years.6,9 CARMELINA® studied the impact of Trajenta® (linagliptin) on cardiovascular and kidney …

How much does gliclazide reduce HbA1c?

In the present study, usage of gliclazide or gliclazide + metformin as monotherapy or as recent add-on to other antihyperglycemic agents resulted in an overall HbA1c reduction of 1.1% in patients with baseline HbA1c ≥ 6.5% after at least 90 days of treatment.

What is Sprint study?

The Systolic Blood Pressure Intervention Trial (SPRINT) is a 2-arm, multicenter, randomized clinical trial designed to test whether a treatment program aimed at reducing systolic blood pressure (SBP) to a lower goal than currently recommended will reduce cardiovascular disease (CVD) risk.

How was BP measured in sprint trial?

The SPRINT trial used programmable automated oscillometric devices to measure BP, but there is confusion in recent publications from investigators not involved with SPRINT regarding whether the BP measurements at the 102 SPRINT clinical sites were unattended.

Can sitagliptin cause heart failure?

In conclusion, sitagliptin increases the risk of heart failure hospitalization within one year of its use, but reduces the risk thereafter. Some factors predisposing to sitagliptin-related heart failure are worthy of attention in clinical practice.

Is Jardiance good for your heart?

Jardiance is also approved to reduce the risk of cardiovascular death in adults with type 2 diabetes and established cardiovascular disease, and to reduce the risk of death and hospitalization in patients with heart failure and low ejection fraction.

Can you take metformin and gliclazide at the same time?

The combined metformin/gliclazide therapy is commonly used for treating T2DM; however, the therapeutic benefits of this combination on oxidative stress, lipid profile, and hepatorenal functions have not been thoroughly studied before.

Does sprinting lower blood pressure?

Longer duration sprints have been shown to improve cardiovascular function and lower blood pressure in young adults [18].