What are interdigitating dendritic cells?

What are interdigitating dendritic cells?

Interdigitating dendritic cells are arachnoid nonlymphoid accessory cells found in the T-cell areas of peripheral lymphoid tissue, including the paracortex and deep cortex of lymph nodes, the splenic periarteriolar lymphoid sheaths, and the interfollicular areas of mucosa-associated lymphoid tissue.

What is follicular dendritic cell sarcoma?

Follicular dendritic cell sarcoma (FDCS) is a rare low-grade sarcoma that most commonly presents as a slowly growing, painless mass with the histologic appearance of spindle-shaped cells in a whorled pattern. Several hundred cases have been reported since it was first described in 1986 [1].

How many types of dendritic cells are there?

Three types of DCs have been defined in human blood: the CD1c+ myeloid DCs, the CD141+ myeloid DCs and the CD303+ plasmacytoid DCs.

What causes follicular dendritic cell sarcoma?

We don’t know what causes follicular dendritic cell sarcoma. It’s particularly difficult to find out the cause of a rare cancer because there are so few people with the disease. This makes it hard to find a common link. Doctors have linked follicular dendritic cell sarcoma to Castleman’s disease.

Where are dendritic cells?

Dendritic cells are found in tissue that has contact with the outside environment such as the over the skin (present as Langerhans cells) and in the linings of the nose, lungs, stomach and intestines.

What is the main function of dendritic cells?

Dendritic cells (DCs) represent a heterogeneous family of immune cells that link innate and adaptive immunity. The main function of these innate cells is to capture, process, and present antigens to adaptive immune cells and mediate their polarization into effector cells (1).

Where is dendritic cells located?

Dendritic cells are found in tissue that has contact with the outside environment such as the over the skin (present as Langerhans cells) and in the linings of the nose, lungs, stomach and intestines. Immature forms are also found in the blood.

What are dendritic cells?

(den-DRIH-tik sel) A special type of immune cell that is found in tissues, such as the skin, and boosts immune responses by showing antigens on its surface to other cells of the immune system. A dendritic cell is a type of phagocyte and a type of antigen-presenting cell (APC).

What is histiocytic sarcoma?

Histiocytic sarcoma (HS) is a rare neoplasia(1-7) of hematopoietic origin characterized by the proliferation of malignant cells that have the morphological and immunohistochemical characteristics of mature tissue histiocytes.

What are the four types of dendritic cells?

To differentiate between the two types of dendritic cells, markers BDCA-2, BDCA-3, and BDCA-4 are used. Another type of dendritic cell is the follicular dendritic cell or fDC. Unlike the myeloid and plasmacytoid forms, these dendritic cells are not of hematopoietic origin and do not express MHC class II.

What is another name for dendritic cells?

accessory cells
Dendritic cells (DCs) are antigen-presenting cells (also known as accessory cells) of the mammalian immune system. Their main function is to process antigen material and present it on the cell surface to the T cells of the immune system.

Why are dendritic cells the best APC?

Dendritic cells are the most effective at presenting peptide antigens to T cells, especially tumor and viral antigens of intracellular origin, because they have the ability to “cross-present” antigens.

Can histiocytic sarcoma be cured?

Disseminated HS affects many different organs. Chemotherapy can be used to slow progression of disease, but prognosis is poor with most patients only living a few months. Hemophagocytic HS is the most aggressive subtype. No effective treatments exist and survival times are only one to two months.

Is histiocytic sarcoma painful?

Untreated, the clinical course of disseminated histiocytic sarcoma is rapid and fatal. Localized histiocytic sarcoma is sometimes more slowly progressive, but can be extremely painful and cause a poor quality of life.

Are dendritic cells lymphoid or myeloid?

Figure 1. Converging plasmacytoid dendritic cell differentiation pathways. Plasmacytoid dendritic cells (pDCs) can be derived from both myeloid and lymphoid progenitors. Common DC progenitors (CDPs) arise from lymphoid primed multipotent progenitors (LMPPs) either directly or via macrophage-DC progenitors (MDPs).

Is MHC the same as HLA?

The human MHC is also called the HLA (human leukocyte antigen) complex (often just the HLA).