Table of Contents
Does JEVTANA cause hair loss?
Temporary hair loss may occur. Normal hair growth should return after treatment has ended. Many people using this medication develop serious side effects.
How is JEVTANA given?
JEVTANA is given through an intravenous infusion by a trained professional.
How do you administer cabazitaxel?
The recommended dose of JEVTANA is based on calculation of the Body Surface Area (BSA), and is 20 mg/m2 administered as a one-hour intravenous infusion every three weeks in combination with oral prednisone 10 mg administered daily throughout JEVTANA treatment.
Is cabazitaxel FDA approved?
On September 14, 2017, the U.S. Food and Drug Administration approved a lower dose of cabazitaxel (20 mg/m2 every 3 weeks) (JEVTANA, Sanofi-Aventis) in combination with prednisone for the treatment of patients with metastatic castration-resistant prostate cancer previously treated with a docetaxel-containing treatment …
Is cabazitaxel stronger than docetaxel?
Cabazitaxel at two different doses was no better than docetaxel with regard to overall survival (OS) or progression-free survival (PFS) in men with metastatic castration-resistant prostate cancer (mCRPC), according to results of the phase III FIRSTANA trial.
What are the side effects of cabazitaxel?
Side Effects
- Black, tarry stools.
- bloating or swelling of the face, arms, hands, lower legs, or feet.
- blood in the urine or stools.
- burning, numbness, tingling, or painful sensations.
- chest pain.
- difficult or labored breathing.
- difficult or painful urination.
- pinpoint red spots on the skin.
How long do you take jevtana?
You have cabazitaxel in cycles of treatment. Each cycle is a 3 week period. This means that you have a cabazitaxel drip once every 3 weeks. You also take steroids (prednisolone) as tablets every morning, after breakfast.
How much does jevtana cost?
The cost for Jevtana intravenous solution (60 mg/1.5 mL) is around $13,199 for a supply of 1.5 milliliters, depending on the pharmacy you visit.
Does cabazitaxel need a filter?
2.6 Administration The final JEVTANA infusion solution should be administered intravenously as a one-hour infusion at room temperature. Use an in-line filter of 0.22 micrometer nominal pore size during administration. The final JEVTANA infusion solution should be used immediately.
Is cabazitaxel cytotoxic?
Cabazitaxel is a derivative of docetaxel, which is cytotoxic for docetaxel-resistant cell lines due to gp-1 overexpression and has a better blood–brain barrier penetration.
Does cabazitaxel lower PSA?
Results: Of the 527 men (median age 72 years), 266 received ≥ 4 cycles of cabazitaxel and had PSA response data. After four cycles, 34.6% of men achieved a PSA decrease ≥ 50% and 49.6% a decrease ≥ 30%.
How does cabazitaxel work?
Cabazitaxel works by stopping cancer cells from separating into two new cells. This blocks the growth of the cancer.
Does cabazitaxel cause neuropathy?
You may lose some feeling in your hands and/or feet, or you may feel tingling or burning in your hands and/or feet. This is called peripheral neuropathy. This side effect may increase with continued treatment.
Is Jevtana a chemotherapy?
Cabazitaxel is a type of chemotherapy. You might have it as a treatment for prostate cancer that has spread (advanced prostate cancer).
Can you drink alcohol with cabazitaxel?
The drinking of alcohol (in small amounts) does not appear to affect the safety or usefulness of cabazitaxel. is best to use birth control while being treated with cabazitaxel and for six months following the last dose. Tell your doctor right away if you or your partner becomes pregnant.
What is cabazitaxel used for?
Cabazitaxel injection is given together with a steroid medicine (eg, prednisone) to treat men with metastatic (cancer that has already spread) castration-resistant prostate cancer (prostate cancer that cannot be treated by surgery or medicines that lower testosterone).
How much does Jevtana cost?
Does cabazitaxel cause back pain?
You may get pain in your muscles or joints for a few days after treatment. If this happens, tell your doctor so they can give you painkillers. Tell them if the pain does not get better.
What is the chemical name of cabazitaxel?
The chemical name of cabazitaxel is (2α,5β,7β,10β,13α)-4-acetoxy-13- ( { (2R,3S)-3- [ (tertbutoxycarbonyl) amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1-hydroxy-7,10-dimethoxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate – propan-2-one (1:1). Cabazitaxel has the following structural formula:
What are the possible adverse effects of cabazitaxel?
In an embryo-fetal developmental toxicity study in rats, cabazitaxel caused maternal and embryo-fetal toxicity consisting of increased postimplantation loss, embryolethality, and fetal deaths when administered intravenously at a dose of 0.16 mg/kg/day (approximately 0.06 times the C max in patients at the recommended human dose).
Does Jevtana interact with cabazitaxel?
A drug interaction study of JEVTANA in 13 patients with advanced cancers has shown that repeated administration of aprepitant (125 or 80 mg once daily), a moderate CYP3A inhibitor, did not modify the exposure to cabazitaxel (15 mg/m 2 intravenous).